Figlio di uno psicologo infantile e di un'insegnante, fratello dell'attore Colin Cheadle, Don Cheadle è nato a Kansas City, ma si è trasferito, piccolissimo, nel Colorado, dove ha frequentato la East High School di Denver e la BFA, studiando recitazione. Verso la fine degli anni novanta inizia a lavorare in film importanti e di successo come Boogie Nights - L'altra Hollywood, Bulworth - Il senatore e Out of Sight di Steven Soderbergh. During high school, he played saxophone in the jazz band, sang in the choirs and was active in the theater department, perform…
Cheadle has campaigned to end the genocide in Darfur, Sudan, and co-authored, with John Prendergast, on a book about this issue; Not On Our Watch: The Mission to End Genocide in Darfur and Beyond.
He made a cameo appearance in the film Abby Singer.
Con la famiglia si trasferisce nel Colorado, dove si diploma alla East High School di Denver, successivamente frequenta la California Institute of the Arts. Brother of Private and Private.
The Blacker the Content the Sweeter the Truth. Cheadle was born in Kansas City, Missouri, to Bettye Cheadle (née North), a teacher, and Donald Frank Cheadle Sr., a clinical psychologist.
Dopo una lunga gavetta televisiva, che lo vede partecipare ad alcuni episodi di serie TV come Saranno famosi ed Avvocati a Los Angeles, nel 1985 debutta in un ruolo minore nel film Scuola guida, poi nel 1987 recita nel film di John Irvin Hamburger Hill: collina 937, mentre nel 1988 recita in Colors - Colori di guerra.  He later guest-starred again in 2020 during Season 3 after a wish Donald made to Gene the Genie had altered reality. They think, 'Well, I don't want to work with him. Donald Frank Cheadle was born in Kansas City, Missouri on November 29, 1964.
", Don was lucky enough to grow up knowing his paternal great-grandmother, Clennie Carroll, who was born in Blackwater, Mo., in 1886. " Cheadle and McGruder were slated to serve as executive producers, while McGruder was expected to write the script. She was very, very smart, very aware of everything.
- Medici in prima linea e lavora nel film indipendente Il delitto Fitzgerald, ma è il 2004 l'anno della svolta, infatti recita nel premio Oscar Crash - Contatto fisico e viene nominato all'Oscar come il miglior attore protagonista per il film Hotel Rwanda.
Cheadle went on to attend the California Institute of the Arts, graduating with a Bachelor of Fine Arts (BFA) in Theater in 1986.
Cheadle first received widespread notice for his portrayal of Mouse Alexander in the film Devil in a Blue Dress, for which he won Best Supporting Actor awards from the Los Angeles Film Critics Association and the National Society of Film Critics and was nominated for similar awards from the Screen Actors Guild and the NAACP Image Awards. You can think of yourself as a colourless person, but nobody else is gonna.
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